A Slow Axon Antidromic Blockade Hypothesis for Tremor Reduction via Deep Brain Stimulation
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چکیده
منابع مشابه
Correction: A Slow Axon Antidromic Blockade Hypothesis for Tremor Reduction via Deep Brain Stimulation
There is an error in Equation 1. Please see the corrected Equation 1 here. P transmissionDl,t ð Þ ~ 0 when 2t §l 1{2t=l when 2tƒl: The first paragraph of the ''Biomechanical Model'' subsection of the Methods contains multiple errors. The correct paragraph is: A simple biomechanical model of the motor control loop is employed to illustrate and check the main characteristics of the hypothesis (Fi...
متن کاملA Slow Axon Antidromic Blockade Hypothesis for Tremor Reduction via Deep Brain Stimulation
Parkinsonian and essential tremor can often be effectively treated by deep brain stimulation. We propose a novel explanation for the mechanism by which this technique ameliorates tremor: a reduction of the delay in the relevant motor control loops via preferential antidromic blockade of slow axons. The antidromic blockade is preferential because the pulses more rapidly clear fast axons, and the...
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OBJECT Deep brain stimulation (DBS) performed under general anesthesia ("asleep" DBS) has not been previously reported for essential tremor. This is in part due to the inability to visualize the target (the ventral intermediate nucleus [VIM]) on MRI. The authors evaluate the efficacy of this asleep technique in treating essential tremor by indirect VIM targeting. METHODS The authors retrospecti...
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BACKGROUND Orthostatic tremor is an uncommon disorder manifest by high frequency, low amplitude leg tremor upon weight bearing. Treatment with oral tremor agents is inconsistent and usually not satisfactory. METHODS We implanted bilateral ventralis intermedius nuclei deep brain stimulators into an 82-year-old male with refractory orthostatic tremor. RESULTS The patient had a marked subjecti...
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OBJECTIVES To evaluate the efficacy of deep brain stimulation (DBS) in the treatment of tremor resulting from acquired brain injury (ABI). METHODS A series of eight consecutive patients with post-ABI tremor were treated with DBS of the ventro-oralis posterior (VOP)/zona incerta (ZI) region, and subsequently underwent blinded assessments using Bain's tremor severity scale. RESULTS VOP/ZI DBS...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0073456